Margaret Ashcroft Selected Research

Proteins (Proteins, Gene)

1/2019	CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain.
1/2018	VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function.
1/2017	Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.
6/2013	Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
4/2012	A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration.
2/2012	Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.
2/2009	Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone.
1/2008	Regulation of angiogenic factors by HDM2 in renal cell carcinoma.
6/2006	Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway.
6/2005	Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors.

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Margaret Ashcroft Research Topics

Disease

30	Hypoxia (Hypoxemia) 03/2023 - 03/2004
17	Neoplasms (Cancer) 01/2021 - 03/2004
3	Renal Cell Carcinoma (Grawitz Tumor) 01/2018 - 06/2006
3	Neoplasm Metastasis (Metastasis) 01/2015 - 01/2004
2	Carcinogenesis 01/2021 - 01/2017
2	Inflammation (Inflammations) 01/2017 - 06/2013
2	Infections 01/2017 - 04/2012
1	Ischemic Stroke 03/2023
1	COVID-19 01/2021
1	Fibrosis (Cirrhosis) 01/2017
1	Kidney Diseases (Kidney Disease) 01/2017
1	Pathologic Processes 01/2017
1	Myocardial Infarction 10/2014
1	Reperfusion Injury 10/2014
1	Prolactinoma (Prolactinomas) 09/2013
1	Hepatocellular Carcinoma (Hepatoma) 04/2012
1	Kidney Neoplasms (Kidney Cancer) 07/2011
1	Ischemia 04/2010
1	Crohn Disease (Crohn's Disease) 11/2009
1	Osteosarcoma (Osteogenic Sarcoma) 06/2005

Drug/Important Bio-Agent (IBA)

10	Oxygen (Dioxygen)IBA 01/2021 - 05/2004
10	Proteins (Proteins, Gene)FDA Link 01/2019 - 06/2005
7	Transcription Factors (Transcription Factor)IBA 01/2018 - 04/2005
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 07/2005
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2012 - 03/2004
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2012 - 06/2006
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 11/2009
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2017 - 02/2012
2	Phosphotransferases (Kinase)IBA 02/2009 - 01/2008
2	Small Interfering RNA (siRNA)IBA 01/2008 - 06/2006
2	NSC-134754IBA 06/2006 - 06/2005
1	methyl malonateIBA 03/2023
1	Cardiolipins (Cardiolipin)IBA 12/2021
1	Galactose (Galactopyranose)FDA LinkGeneric 01/2021
1	romidepsin (FK228)FDA Link 01/2020
1	Histone Deacetylase InhibitorsIBA 01/2020
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2019
1	Ligases (Synthetase)IBA 01/2018
1	Tetradecanoylphorbol AcetateIBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2017
1	Mitochondrial DNA (mtDNA)IBA 01/2017
1	lysophosphatidic acidIBA 01/2017
1	LipidsIBA 01/2017
1	Phospholipases (Phospholipase)IBA 01/2017
1	Messenger RNA (mRNA)IBA 01/2017
1	ADI PEG20IBA 03/2016
1	Arginine (L-Arginine)FDA Link 03/2016
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2016
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/2014
1	Mitochondrial Permeability Transition PoreIBA 10/2014
1	azomycinIBA 09/2013
1	carbogenIBA 09/2013
1	pimonidazoleIBA 09/2013
1	CCI 103FIBA 09/2013
1	Biomarkers (Surrogate Marker)IBA 09/2013
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 06/2013
1	p38 Mitogen-Activated Protein KinasesIBA 06/2013
1	TNF Receptor-Associated Factor 6 (TRAF6)IBA 06/2013
1	UbiquitinIBA 06/2013
1	Deubiquitinating EnzymesIBA 06/2013
1	Glycoproteins (Glycoprotein)IBA 04/2012
1	Transforming Growth Factor beta (TGF-beta)IBA 04/2012
1	AntioxidantsIBA 02/2012
1	neuromedin UIBA 07/2011
1	oxalylglycineIBA 07/2011
1	EnzymesIBA 04/2010
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 04/2010
1	Phorbol EstersIBA 11/2009
1	Tumor Suppressor Protein p53IBA 04/2009
1	NSC 652287IBA 04/2009
1	furanIBA 04/2009
1	Follicle Stimulating Hormone (Follitropin)FDA Link 02/2009
1	endothelial PAS domain-containing protein 1IBA 01/2008
1	Oncogene Proteins (Oncogene Protein)IBA 01/2008
1	Plasminogen Activators (Plasminogen Activator)IBA 06/2006
1	Urokinase Plasminogen Activator ReceptorsIBA 06/2006
1	Insulin-Like PeptidesIBA 06/2006
1	Insulin-Like Growth Factor I (IGF-1)IBA 06/2006
1	LuciferasesIBA 06/2005
1	Deferoxamine (Desferal)FDA LinkGeneric 06/2005
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2004

Therapy/Procedure

6	Therapeutics 03/2016 - 03/2004
1	Tracheostomy 01/2021
1	Radiotherapy 01/2015
1	Drug Therapy (Chemotherapy) 01/2015